[PDF] Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom -- Herbal Medicine: Biomolecular and Clinical Aspects | Semantic Scholar (2025)

Clinical and pharmacological studies showed that G. lucidum is composed of hundreds of bioactive components with immunomodulatory, antioxidant, antiaging, antiviral, Connection of Ganoderma Lucidum with Health.

Recent knowledge on phytochemical and pharmacological compositions, therapeutic and side effects, clinical trials, and commercial products of G. lucidum is intended to give and discuss.

This species of Ganoderma medicinal mushroom is used extensively for its internal effect on improving immune system, hepatoprotective benefit and additionally, a large variety of people consume GanoderMA lucidum as tea infusion and coffee because its antioxidant and reducing stress effects.

Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti -metastatic and anti-angiogenic effects.

Treatment and various pharmacological mechanism against tumor with respect to extract (polysaccharide and triterpenoid) of Ganoderma lucidum are reviewed.

This chapter describes the details of this special mushroom, including its taxonomy, morphology, ecological and economic status, cultivation, bioactive molecules, and its medicinal applications.

It would be the right approach to abstain from using and incentivizing this product, until its benefits and harms are set out clearly, by considering its potential side effects.

A review of the literature showed that there are very few papers that studied semisolid dosage forms preparations based of Ganoderma lucidum extract to have been used on damaged skin and skin diseases, neither have there been enough studies on its anti-aging properties.

An extensive overview of the presence of antitumour, antimicrobial, antioxidant and antiacetylcholinesterase compounds in G. lucidum extracts will be given, along with an evaluation of their therapeutic effects.

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Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes, and playing a significant role in various therapeutic applications.

This review summarizes the biological effects of Ganoderma lucidum upon specific signaling molecules and pathways, which are responsible for its therapeutic effects.

A water extract of the Oriental crude drug "reishi", the fruit bodies of GANODERMA LUCIDUM, significantly decreased plasma sugar level in mice and elicited remarkable hypoglycemic actions in normal and alloxan-induced hyperglycemic mice.

To investigate antitumor components of Korean higher fungi, the carpophores of Ganoderma lucidum (Fr.)Karst were collected and found to be a complex of polysaccharide and protein, from which four monosaccharides and eighteen amino acids were identified.

Overall, G. lucidum and G. tsugae were higher in antioxidant activity, reducing power, scavenging and chelating abilities, and total phenol content.

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